We have shown that a gene called p11 is involved in the multiple complex changes that underlie depression. Our findings demonstrate that patients with depression, and mice that model this disease, have decreased levels of p11 protein, and they suggest that drugs that increase p11 are likely to have anti-depressant properties.

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We have shown that a gene (or protein) called p11 is involved in the multiple complex changes that underlie depression.

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In addition to exploring ways to increase p11 in depressed patients, it may also be possible to develop peptide-based compounds that can mimic the action of p11 to achieve a new class of anti-depressant compounds.

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