"Salim Yusuf" is an Indian-born Canada/Canadian physician and Marion W. Burke Chair in Cardiovascular Disease at McMaster University Medical School. He is a world-renowned cardiologist and epidemiologist. In 2001, he published a landmark study that proved the benefits of clopidogrel in acute coronary syndrome without ST elevation.

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Most of us think of obesity as a problem of rich and western industrialized countries. But our data shows that it also affects low and middle income countries especially people living in cities.

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Substantial reassessment is needed of the importance of obesity for cardiovascular disease in most regions of the world.

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What we know is that fat in the abdomen, which is associated with a larger waist, is metabolically active and produces various hormones that can cause harmful effects, such as causing diabetes, affecting blood pressure, affecting lipid [blood fat] levels, ... Fat in the abdomen may also relate to fat in the liver, and that makes the liver not function well.

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The future really is to find therapies that are just as effective, but safer.

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This means a short-term therapy that is just as effective at preventing events but is much safer translates in the long term to an important difference.

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The global burden of obesity has been substantially underestimated by the reliance of BMI in previous studies.

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(Angioplasty) is at least a reasonable alternative to (drug) therapy in high-risk patients, and in expert hands, may be preferred in patients prone to stroke, such as the elderly.

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Our findings suggest that substantial reassessment is needed of the importance of obesity for cardiovascular disease in most regions of the world.

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The best index of obesity as a predictor of myocardial infarction is the waist-to-hip ratio.

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