We had previously demonstrated that ATRA is an effective synergist with TPA in treating prostate cancer in the laboratory so it was logical to test the combination against pancreatic cancer as well. We found that the TPA/ATRA combination in cell culture worked better than the individual compounds alone.

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We were simultaneously stopping the growth of new cancer cells and killing those already existing. This was most dramatic when we used the TPA/ATRA combination on the tumors.

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