The cells of obese people remembered their metabolic program, which could help explain, in part, why losing weight and maintaining weight loss is so difficult.

214

We found that obesity was associated with a threefold increase in SCD1 expression in obese muscle, as well as a threefold higher level of SCD1 enzyme, compared to lean muscle.

173

Obesity is a very complex disease, and this metabolic pathway does not fully explain obesity, but it is a likely contributor.

156

Obesity is a very complex disease, and this metabolic pathway probably does not fully explain obesity, but we now know that SCD1 is at least a very important contributor.

133

There are two important observations that might have clinical relevance.

132

While these findings may be somewhat discouraging news for those wishing to reverse obesity through dietary interventions, they also highlight the importance of exercise.

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