In the younger women, the 50- to 59-year-old women, it appeared that there was a suggestion that heart disease risk was lower, but in the older women it was either neutral or possibly even higher.

316

We feel that our data are completely consistent with the current American Heart Association guidelines and the current FDA guidance to use the lowest possible dose for the shortest possible duration.

131

Women who need to take estrogen because of severe menopausal symptoms should take the smallest amount of dose, for the shortest possible amount of time.

105