There is no reason to use the combination therapy for primary prevention, whereas it might be useful in patients who have already had a heart attack or stroke.

I'd say that I, as well as our other investigators, were surprised at the findings.

Part of it is the responsibility of patients and part of it is physicians and trying to keep up with the latest guidelines for how intensively to treat high blood pressure and high cholesterol.

Aspirin is tough to beat, but it too has bleeding risk.

The overall findings were negative, but a benefit was seen in patients with established cardiovascular disease.