Our thinking is that many subclasses of depression might be associated with lower levels of P11 on the one hand, and that raising either the level or the functionality of the P11 would be a novel way of developing antidepressants.
Mice deficient in this protein, called p11, display depression-like behaviors, while those with sufficient amounts behave as if they have been treated with antidepressants.
We're finding that other molecules control other receptors, so I think this may open up quite a major new area of approach to developing therapeutic drugs.
What this discovery showed was that p11 plays a major role in mood.
We're all very excited about this discovery. People have been looking for modulators of serotonin for a long time.
The p11 is upstream of the receptor, and now the question is what is upstream of the p11.
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