This is the first time we have evidence that a drug can actually lessen joint damage in rheumatoid arthritis. It hasn't been clear that drugs can do this.
[Arthritis patients, too, often receive hydrotherapy. The Arthritis Foundation recommends underwater exercise to prevent stiffening and atrophy.] Warm water increases blood flow to joints, plus the heat increases the flexibility of the joints, ... And because of buoyancy, there is less force on the joint, so that one can exercise without pain.
We've been talking about the importance of this study for the last two or three years. This is the most important study ever done. It has a very large number of patients and it is scientifically rigorous.
These studies show many more patients can benefit from taking these two drugs, ... Even though the FDA expanded the indications for their use earlier this year to include patients with moderate to severe disease, many patients are not using them.
These have been a major advance in rheumatology, ... probably the single major advance in at least 50 years. The only thing comparable was the introduction of corticosteroids in the 1950's.
Warm water increases blood flow to joints, plus the heat increases the flexibility of the joints. And because of buoyancy, there is less force on the joint, so that one can exercise without pain.
Most people have both cytokines, so the next question is, would it be better to take both together, would results be much better if both were inhibited.
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