The big bulk of the response to anti-depressants is the placebo response. I don't think these studies are very informative.
"Irving Kirsch" is Associate Director of the Program in Placebo Studies and a lecturer in medicine at the Harvard Medical School and Beth Israel Deaconess Medical Center. He is also professor emeritus of psychology at the Universities of University of Hull/Hull and University of Plymouth/Plymouth in the United Kingdom, and the University of Connecticut in the United States. Kirsch is noted for his research on placebo effects, antidepressants, expectancy, and hypnosis. He is the originator of #Response expectancy theory/response expectancy theory, and his analyses of clinical trials of antidepressants have influenced official treatment guidelines in the United Kingdom. He is the author of the 2009 book, The Emperor's New Drugs.
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