This observation suggests a dramatic and perhaps permanent perturbation of the natural history of the disease, maybe even a cure. Longer follow-up will determine whether this interpretation is correct.

Clearly, the results are not evolutionary but revolutionary.

The results are simply stunning.

Our care of patients with HER2-positive breast cancer must change today.

Clearly, the results reported in this issue of the journal are revolutionary.

We don't know at this point whether these are going to be permanent episodes of heart damage or transient.

On the basis of these results, our care of patients with HER2-positive breast cancer must change today.

The results are simply stunning, ... will completely alter our approach to the treatment of breast cancer.

The strength of the evidence is so overwhelming at this point that it would be almost impossible to withhold this drug from the appropriate group of patients.