We don't see any hint of a reduction in (colorectal cancer). For heart disease, we saw only a tiny reduction in the bad cholesterol.

We think that women who are currently on a low-fat diet can confidently continue on such a diet.

This is a novel study, and although the results seem disappointing to some, we see points of encouragement.

If we had achieved an even higher adherence rate, I believe the study's results would have been more dramatic.

We don't regard our data as strong enough at this time to recommend that all post-menopausal women start a low-fat diet for the purpose of reducing breast cancer risk.

The long-term legacy will be one of encouraging this research area. We need to find that intervention that will make a big difference.

Even though the data are not as precise as we would like, they do bring some fresh and important data to the table that hadn't existed before.

Among the women who made larger reductions in saturated and trans fat we saw trends toward reduction in heart disease.

We did not see evidence of any adverse effects of a low-fat diet, and we see some trends toward health benefits, especially for breast cancer. So, we think that women who are currently on a low-fat diet can confidently continue on such a diet.

I think women who are currently following a low-fat diet should be encouraged to do so. We didn't see any unfavorable effects. For women who are at high risk for breast cancer, they should talk it over with their physicians whether adopting a low-fat diet might be warranted.

Women that are already eating a low-fat diet have every reason to continue.

The bottom line is that changing to a low-fat diet may reduce breast cancer risk, especially among women who have a relatively high-fat diet to begin with, but we don't view our data as strong enough at this time to make a broad recommendation that all women initiate a low-fat diet for that purpose.

We observed that women in the low-fat diet group had a 9 percent lower risk of breast cancer than the usual diet group, but that difference could be due to chance.