Up until now we have chronically underestimated the very substantial differences in the way individuals respond to the same dose of the same drug.

Lots of genes could be important -- genes that determine how you absorb a drug, variations in one gene involved in breaking down the drugs, variations in the way that you excrete a drug.

Although these results are in mice, not people, they raise an exciting possibility which can be tested in humans.

I think aspirin would do exactly what you might expect -- attenuate, but not abolish the risk.