At the very least, I have to have very good visibility into my contract manufacturer in China as to any quality hiccups that might affect me. I need to get early warning of those, and potentially I may have to source locally to remain responsive to fluctuations in demand.

That may be the right time for you to say, 'OK I might need to move production to someone who is quite frankly better at manufacturing lower cost and make room for my next development drug to come through, and I'll move the product whose margins have now been eroded to a contract manufacturer.

Relatively few manufacturers have the luxury to choose a different product mix based on energy prices.